LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors
Identifieur interne : 001302 ( Main/Exploration ); précédent : 001301; suivant : 001303LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors
Auteurs : Kelly M. Hinkle [États-Unis] ; Mei Yue [États-Unis] ; Bahareh Behrouz [États-Unis] ; Justus C. D Chsel [États-Unis] ; Sarah J. Lincoln [États-Unis] ; Erin E. Bowles [États-Unis] ; Joel E. Beevers [États-Unis] ; Brittany Dugger [États-Unis] ; Beate Winner [Allemagne] ; Iryna Prots [Allemagne] ; Caroline B. Kent [États-Unis] ; Kenya Nishioka [États-Unis] ; Wen-Lang Lin [États-Unis] ; Dennis W. Dickson [États-Unis] ; Christopher J. Janus [États-Unis] ; Matthew J. Farrer [États-Unis, Canada] ; Heather L. Melrose [États-Unis]Source :
- Molecular Neurodegeneration [ 1750-1326 ] ; 2012.
Abstract
Mutations in the
We created mice lacking exon 41 that encodes the activation hinge of the kinase domain of LRRK2. We have performed a comprehensive analysis of these mice up to 20 months of age, including evaluation of dopamine storage, release, uptake and synthesis, behavioral testing, dendritic spine and proliferation/neurogenesis analysis.
Our results show that the dopaminergic system was not functionally comprised in
Url:
DOI: 10.1186/1750-1326-7-25
PubMed: 22647713
PubMed Central: 3441373
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000504
- to stream Pmc, to step Curation: 000504
- to stream Pmc, to step Checkpoint: 000876
- to stream Ncbi, to step Merge: 001159
- to stream Ncbi, to step Curation: 001159
- to stream Ncbi, to step Checkpoint: 001159
- to stream Main, to step Merge: 001334
- to stream Main, to step Curation: 001302
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en"><italic>LRRK2</italic> knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors</title><author><name sortKey="Hinkle, Kelly M" sort="Hinkle, Kelly M" uniqKey="Hinkle K" first="Kelly M" last="Hinkle">Kelly M. Hinkle</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224</wicri:regionArea><wicri:noRegion>32224</wicri:noRegion></affiliation></author><author><name sortKey="Yue, Mei" sort="Yue, Mei" uniqKey="Yue M" first="Mei" last="Yue">Mei Yue</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224</wicri:regionArea><wicri:noRegion>32224</wicri:noRegion></affiliation></author><author><name sortKey="Behrouz, Bahareh" sort="Behrouz, Bahareh" uniqKey="Behrouz B" first="Bahareh" last="Behrouz">Bahareh Behrouz</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224</wicri:regionArea><wicri:noRegion>32224</wicri:noRegion></affiliation></author><author><name sortKey="D Chsel, Justus C" sort="D Chsel, Justus C" uniqKey="D Chsel J" first="Justus C" last="D Chsel">Justus C. D Chsel</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224</wicri:regionArea><wicri:noRegion>32224</wicri:noRegion></affiliation></author><author><name sortKey="Lincoln, Sarah J" sort="Lincoln, Sarah J" uniqKey="Lincoln S" first="Sarah J" last="Lincoln">Sarah J. Lincoln</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224</wicri:regionArea><wicri:noRegion>32224</wicri:noRegion></affiliation></author><author><name sortKey="Bowles, Erin E" sort="Bowles, Erin E" uniqKey="Bowles E" first="Erin E" last="Bowles">Erin E. Bowles</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224</wicri:regionArea><wicri:noRegion>32224</wicri:noRegion></affiliation></author><author><name sortKey="Beevers, Joel E" sort="Beevers, Joel E" uniqKey="Beevers J" first="Joel E" last="Beevers">Joel E. Beevers</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224</wicri:regionArea><wicri:noRegion>32224</wicri:noRegion></affiliation></author><author><name sortKey="Dugger, Brittany" sort="Dugger, Brittany" uniqKey="Dugger B" first="Brittany" last="Dugger">Brittany Dugger</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224</wicri:regionArea><wicri:noRegion>32224</wicri:noRegion></affiliation></author><author><name sortKey="Winner, Beate" sort="Winner, Beate" uniqKey="Winner B" first="Beate" last="Winner">Beate Winner</name><affiliation wicri:level="1"><nlm:aff id="I2">Junior Group III, Interdisciplinary Center for Clinical Research, Nikolaus-Fiebiger Center for Molecular Medicine, FAU, Erlangen-Nürnberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Junior Group III, Interdisciplinary Center for Clinical Research, Nikolaus-Fiebiger Center for Molecular Medicine, FAU, Erlangen-Nürnberg</wicri:regionArea><wicri:noRegion>Erlangen-Nürnberg</wicri:noRegion><wicri:noRegion>Erlangen-Nürnberg</wicri:noRegion><wicri:noRegion>Erlangen-Nürnberg</wicri:noRegion></affiliation></author><author><name sortKey="Prots, Iryna" sort="Prots, Iryna" uniqKey="Prots I" first="Iryna" last="Prots">Iryna Prots</name><affiliation wicri:level="1"><nlm:aff id="I2">Junior Group III, Interdisciplinary Center for Clinical Research, Nikolaus-Fiebiger Center for Molecular Medicine, FAU, Erlangen-Nürnberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Junior Group III, Interdisciplinary Center for Clinical Research, Nikolaus-Fiebiger Center for Molecular Medicine, FAU, Erlangen-Nürnberg</wicri:regionArea><wicri:noRegion>Erlangen-Nürnberg</wicri:noRegion><wicri:noRegion>Erlangen-Nürnberg</wicri:noRegion><wicri:noRegion>Erlangen-Nürnberg</wicri:noRegion></affiliation></author><author><name sortKey="Kent, Caroline B" sort="Kent, Caroline B" uniqKey="Kent C" first="Caroline B" last="Kent">Caroline B. Kent</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224</wicri:regionArea><wicri:noRegion>32224</wicri:noRegion></affiliation></author><author><name sortKey="Nishioka, Kenya" sort="Nishioka, Kenya" uniqKey="Nishioka K" first="Kenya" last="Nishioka">Kenya Nishioka</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224</wicri:regionArea><wicri:noRegion>32224</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Wen Lang" sort="Lin, Wen Lang" uniqKey="Lin W" first="Wen-Lang" last="Lin">Wen-Lang Lin</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224</wicri:regionArea><wicri:noRegion>32224</wicri:noRegion></affiliation></author><author><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W" last="Dickson">Dennis W. Dickson</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224</wicri:regionArea><wicri:noRegion>32224</wicri:noRegion></affiliation></author><author><name sortKey="Janus, Christopher J" sort="Janus, Christopher J" uniqKey="Janus C" first="Christopher J" last="Janus">Christopher J. Janus</name><affiliation wicri:level="1"><nlm:aff id="I3">Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, Florida, 32610, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, Florida, 32610</wicri:regionArea><wicri:noRegion>32610</wicri:noRegion></affiliation></author><author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J" last="Farrer">Matthew J. Farrer</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224</wicri:regionArea><wicri:noRegion>32224</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I4">Department of Medical Genetics, University of British Columbia, Vancouver, V6T 285, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Genetics, University of British Columbia, Vancouver, V6T 285</wicri:regionArea><wicri:noRegion>V6T 285</wicri:noRegion></affiliation></author><author><name sortKey="Melrose, Heather L" sort="Melrose, Heather L" uniqKey="Melrose H" first="Heather L" last="Melrose">Heather L. Melrose</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224</wicri:regionArea><wicri:noRegion>32224</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22647713</idno><idno type="pmc">3441373</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441373</idno><idno type="RBID">PMC:3441373</idno><idno type="doi">10.1186/1750-1326-7-25</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000504</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000504</idno><idno type="wicri:Area/Pmc/Curation">000504</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000504</idno><idno type="wicri:Area/Pmc/Checkpoint">000876</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000876</idno><idno type="wicri:Area/Ncbi/Merge">001159</idno><idno type="wicri:Area/Ncbi/Curation">001159</idno><idno type="wicri:Area/Ncbi/Checkpoint">001159</idno><idno type="wicri:Area/Main/Merge">001334</idno><idno type="wicri:Area/Main/Curation">001302</idno><idno type="wicri:Area/Main/Exploration">001302</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>LRRK2</italic> knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors</title><author><name sortKey="Hinkle, Kelly M" sort="Hinkle, Kelly M" uniqKey="Hinkle K" first="Kelly M" last="Hinkle">Kelly M. Hinkle</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224</wicri:regionArea><wicri:noRegion>32224</wicri:noRegion></affiliation></author><author><name sortKey="Yue, Mei" sort="Yue, Mei" uniqKey="Yue M" first="Mei" last="Yue">Mei Yue</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224</wicri:regionArea><wicri:noRegion>32224</wicri:noRegion></affiliation></author><author><name sortKey="Behrouz, Bahareh" sort="Behrouz, Bahareh" uniqKey="Behrouz B" first="Bahareh" last="Behrouz">Bahareh Behrouz</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224</wicri:regionArea><wicri:noRegion>32224</wicri:noRegion></affiliation></author><author><name sortKey="D Chsel, Justus C" sort="D Chsel, Justus C" uniqKey="D Chsel J" first="Justus C" last="D Chsel">Justus C. D Chsel</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224</wicri:regionArea><wicri:noRegion>32224</wicri:noRegion></affiliation></author><author><name sortKey="Lincoln, Sarah J" sort="Lincoln, Sarah J" uniqKey="Lincoln S" first="Sarah J" last="Lincoln">Sarah J. Lincoln</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224</wicri:regionArea><wicri:noRegion>32224</wicri:noRegion></affiliation></author><author><name sortKey="Bowles, Erin E" sort="Bowles, Erin E" uniqKey="Bowles E" first="Erin E" last="Bowles">Erin E. Bowles</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224</wicri:regionArea><wicri:noRegion>32224</wicri:noRegion></affiliation></author><author><name sortKey="Beevers, Joel E" sort="Beevers, Joel E" uniqKey="Beevers J" first="Joel E" last="Beevers">Joel E. Beevers</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224</wicri:regionArea><wicri:noRegion>32224</wicri:noRegion></affiliation></author><author><name sortKey="Dugger, Brittany" sort="Dugger, Brittany" uniqKey="Dugger B" first="Brittany" last="Dugger">Brittany Dugger</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224</wicri:regionArea><wicri:noRegion>32224</wicri:noRegion></affiliation></author><author><name sortKey="Winner, Beate" sort="Winner, Beate" uniqKey="Winner B" first="Beate" last="Winner">Beate Winner</name><affiliation wicri:level="1"><nlm:aff id="I2">Junior Group III, Interdisciplinary Center for Clinical Research, Nikolaus-Fiebiger Center for Molecular Medicine, FAU, Erlangen-Nürnberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Junior Group III, Interdisciplinary Center for Clinical Research, Nikolaus-Fiebiger Center for Molecular Medicine, FAU, Erlangen-Nürnberg</wicri:regionArea><wicri:noRegion>Erlangen-Nürnberg</wicri:noRegion><wicri:noRegion>Erlangen-Nürnberg</wicri:noRegion><wicri:noRegion>Erlangen-Nürnberg</wicri:noRegion></affiliation></author><author><name sortKey="Prots, Iryna" sort="Prots, Iryna" uniqKey="Prots I" first="Iryna" last="Prots">Iryna Prots</name><affiliation wicri:level="1"><nlm:aff id="I2">Junior Group III, Interdisciplinary Center for Clinical Research, Nikolaus-Fiebiger Center for Molecular Medicine, FAU, Erlangen-Nürnberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Junior Group III, Interdisciplinary Center for Clinical Research, Nikolaus-Fiebiger Center for Molecular Medicine, FAU, Erlangen-Nürnberg</wicri:regionArea><wicri:noRegion>Erlangen-Nürnberg</wicri:noRegion><wicri:noRegion>Erlangen-Nürnberg</wicri:noRegion><wicri:noRegion>Erlangen-Nürnberg</wicri:noRegion></affiliation></author><author><name sortKey="Kent, Caroline B" sort="Kent, Caroline B" uniqKey="Kent C" first="Caroline B" last="Kent">Caroline B. Kent</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224</wicri:regionArea><wicri:noRegion>32224</wicri:noRegion></affiliation></author><author><name sortKey="Nishioka, Kenya" sort="Nishioka, Kenya" uniqKey="Nishioka K" first="Kenya" last="Nishioka">Kenya Nishioka</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224</wicri:regionArea><wicri:noRegion>32224</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Wen Lang" sort="Lin, Wen Lang" uniqKey="Lin W" first="Wen-Lang" last="Lin">Wen-Lang Lin</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224</wicri:regionArea><wicri:noRegion>32224</wicri:noRegion></affiliation></author><author><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W" last="Dickson">Dennis W. Dickson</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224</wicri:regionArea><wicri:noRegion>32224</wicri:noRegion></affiliation></author><author><name sortKey="Janus, Christopher J" sort="Janus, Christopher J" uniqKey="Janus C" first="Christopher J" last="Janus">Christopher J. Janus</name><affiliation wicri:level="1"><nlm:aff id="I3">Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, Florida, 32610, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, Florida, 32610</wicri:regionArea><wicri:noRegion>32610</wicri:noRegion></affiliation></author><author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J" last="Farrer">Matthew J. Farrer</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224</wicri:regionArea><wicri:noRegion>32224</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I4">Department of Medical Genetics, University of British Columbia, Vancouver, V6T 285, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Genetics, University of British Columbia, Vancouver, V6T 285</wicri:regionArea><wicri:noRegion>V6T 285</wicri:noRegion></affiliation></author><author><name sortKey="Melrose, Heather L" sort="Melrose, Heather L" uniqKey="Melrose H" first="Heather L" last="Melrose">Heather L. Melrose</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224</wicri:regionArea><wicri:noRegion>32224</wicri:noRegion></affiliation></author></analytic><series><title level="j">Molecular Neurodegeneration</title><idno type="eISSN">1750-1326</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Mutations in the <italic>LRRK2</italic> gene are the most common cause of genetic Parkinson’s disease. Although the mechanisms behind the pathogenic effects of <italic>LRRK2</italic> mutations are still not clear, data emerging from <italic>in vitro</italic> and <italic>in vivo</italic> models suggests roles in regulating neuronal polarity, neurotransmission, membrane and cytoskeletal dynamics and protein degradation.</p><p>We created mice lacking exon 41 that encodes the activation hinge of the kinase domain of LRRK2. We have performed a comprehensive analysis of these mice up to 20 months of age, including evaluation of dopamine storage, release, uptake and synthesis, behavioral testing, dendritic spine and proliferation/neurogenesis analysis.</p><p>Our results show that the dopaminergic system was not functionally comprised in <italic>LRRK2</italic> knockout mice. However, <italic>LRRK2</italic> knockout mice displayed abnormal exploratory activity in the open-field test. Moreover, <italic>LRRK2</italic> knockout mice stayed longer than their wild type littermates on the accelerated rod during rotarod testing. Finally, we confirm that loss of LRRK2 caused degeneration in the kidney, accompanied by a progressive enhancement of autophagic activity and accumulation of autofluorescent material, but without evidence of biphasic changes.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zimprich, A" uniqKey="Zimprich A">A Zimprich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paisan Ruiz, C" uniqKey="Paisan Ruiz C">C Paisan-Ruiz</name></author><author><name sortKey="Evans, Ew" uniqKey="Evans E">EW Evans</name></author><author><name sortKey="Jain, S" uniqKey="Jain S">S Jain</name></author><author><name sortKey="Xiromerisiou, G" uniqKey="Xiromerisiou G">G Xiromerisiou</name></author><author><name sortKey="Gibbs, Jr" uniqKey="Gibbs J">JR Gibbs</name></author><author><name sortKey="Eerola, J" uniqKey="Eerola J">J Eerola</name></author><author><name sortKey="Gourbali, V" uniqKey="Gourbali V">V Gourbali</name></author><author><name sortKey="Hellstrom, O" uniqKey="Hellstrom O">O Hellstrom</name></author><author><name sortKey="Duckworth, J" uniqKey="Duckworth J">J Duckworth</name></author><author><name sortKey="Papadimitriou, A" uniqKey="Papadimitriou A">A Papadimitriou</name></author><author><name sortKey="Tienari, Pj" uniqKey="Tienari P">PJ Tienari</name></author><author><name sortKey="Hadjigeorgiou, Gm" uniqKey="Hadjigeorgiou G">GM Hadjigeorgiou</name></author><author><name sortKey="Singleton, Ab" uniqKey="Singleton A">AB Singleton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kachergus, J" uniqKey="Kachergus J">J Kachergus</name></author><author><name sortKey="Mata, If" uniqKey="Mata I">IF Mata</name></author><author><name sortKey="Hulihan, M" uniqKey="Hulihan M">M Hulihan</name></author><author><name sortKey="Taylor, Jp" uniqKey="Taylor J">JP Taylor</name></author><author><name sortKey="Lincoln, S" uniqKey="Lincoln S">S Lincoln</name></author><author><name sortKey="Aasly, J" uniqKey="Aasly J">J Aasly</name></author><author><name sortKey="Gibson, Jm" uniqKey="Gibson J">JM Gibson</name></author><author><name sortKey="Ross, Oa" uniqKey="Ross O">OA Ross</name></author><author><name sortKey="Lynch, T" uniqKey="Lynch T">T Lynch</name></author><author><name sortKey="Wiley, J" uniqKey="Wiley J">J Wiley</name></author><author><name sortKey="Payami, H" uniqKey="Payami H">H Payami</name></author><author><name sortKey="Nutt, J" uniqKey="Nutt J">J Nutt</name></author><author><name sortKey="Maraganore, Dm" uniqKey="Maraganore D">DM Maraganore</name></author><author><name sortKey="Czyzewski, K" uniqKey="Czyzewski K">K Czyzewski</name></author><author><name sortKey="Styczynska, M" uniqKey="Styczynska M">M Styczynska</name></author><author><name sortKey="Wszolek, Zk" uniqKey="Wszolek Z">ZK Wszolek</name></author><author><name sortKey="Farrer, Mj" uniqKey="Farrer M">MJ Farrer</name></author><author><name sortKey="Toft, M" uniqKey="Toft M">M Toft</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ozelius, Lj" uniqKey="Ozelius L">LJ Ozelius</name></author><author><name sortKey="Senthil, G" uniqKey="Senthil G">G Senthil</name></author><author><name sortKey="Saunders Pullman, R" uniqKey="Saunders Pullman R">R Saunders-Pullman</name></author><author><name sortKey="Ohmann, E" uniqKey="Ohmann E">E Ohmann</name></author><author><name sortKey="Deligtisch, A" uniqKey="Deligtisch A">A Deligtisch</name></author><author><name sortKey="Tagliati, M" uniqKey="Tagliati M">M Tagliati</name></author><author><name sortKey="Hunt, Al" uniqKey="Hunt A">AL Hunt</name></author><author><name sortKey="Klein, C" uniqKey="Klein C">C Klein</name></author><author><name sortKey="Henick, B" uniqKey="Henick B">B Henick</name></author><author><name sortKey="Hailpern, Sm" uniqKey="Hailpern S">SM Hailpern</name></author><author><name sortKey="Lipton, Rb" uniqKey="Lipton R">RB Lipton</name></author><author><name sortKey="Soto Valencia, J" uniqKey="Soto Valencia J">J Soto-Valencia</name></author><author><name sortKey="Risch, N" uniqKey="Risch N">N Risch</name></author><author><name sortKey="Bressman, Sb" uniqKey="Bressman S">SB Bressman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ishihara, L" uniqKey="Ishihara L">L Ishihara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Di Fonzo, A" uniqKey="Di Fonzo A">A Di Fonzo</name></author><author><name sortKey="Wu Chou, Yh" uniqKey="Wu Chou Y">YH Wu-Chou</name></author><author><name sortKey="Lu, Cs" uniqKey="Lu C">CS Lu</name></author><author><name sortKey="Van Doeselaar, M" uniqKey="Van Doeselaar M">M van Doeselaar</name></author><author><name sortKey="Simons, Ej" uniqKey="Simons E">EJ Simons</name></author><author><name sortKey="Rohe, Cf" uniqKey="Rohe C">CF Rohe</name></author><author><name sortKey="Chang, Hc" uniqKey="Chang H">HC Chang</name></author><author><name sortKey="Chen, Rs" uniqKey="Chen R">RS Chen</name></author><author><name sortKey="Weng, Yh" uniqKey="Weng Y">YH Weng</name></author><author><name sortKey="Vanacore, N" uniqKey="Vanacore N">N Vanacore</name></author><author><name sortKey="Breedveld, Gj" uniqKey="Breedveld G">GJ Breedveld</name></author><author><name sortKey="Oostra, Ba" uniqKey="Oostra B">BA Oostra</name></author><author><name sortKey="Bonifati, V" uniqKey="Bonifati V">V Bonifati</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tan, Ek" uniqKey="Tan E">EK Tan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Farrer, Mj" uniqKey="Farrer M">MJ Farrer</name></author><author><name sortKey="Stone, Jt" uniqKey="Stone J">JT Stone</name></author><author><name sortKey="Lin, Ch" uniqKey="Lin C">CH Lin</name></author><author><name sortKey="Dachsel, Jc" uniqKey="Dachsel J">JC Dachsel</name></author><author><name sortKey="Hulihan, Mm" uniqKey="Hulihan M">MM Hulihan</name></author><author><name sortKey="Haugarvoll, K" uniqKey="Haugarvoll K">K Haugarvoll</name></author><author><name sortKey="Ross, Oa" uniqKey="Ross O">OA Ross</name></author><author><name sortKey="Wu, Rm" uniqKey="Wu R">RM Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ross, Oa" uniqKey="Ross O">OA Ross</name></author><author><name sortKey="Wu, Yr" uniqKey="Wu Y">YR Wu</name></author><author><name sortKey="Lee, Mc" uniqKey="Lee M">MC Lee</name></author><author><name sortKey="Funayama, M" uniqKey="Funayama M">M Funayama</name></author><author><name sortKey="Chen, Ml" uniqKey="Chen M">ML Chen</name></author><author><name sortKey="Soto, Ai" uniqKey="Soto A">AI Soto</name></author><author><name sortKey="Mata, If" uniqKey="Mata I">IF Mata</name></author><author><name sortKey="Lee Chen, Gj" uniqKey="Lee Chen G">GJ Lee-Chen</name></author><author><name sortKey="Chen, Cm" uniqKey="Chen C">CM Chen</name></author><author><name sortKey="Tang, M" uniqKey="Tang M">M Tang</name></author><author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y Zhao</name></author><author><name sortKey="Hattori, N" uniqKey="Hattori N">N Hattori</name></author><author><name sortKey="Farrer, Mj" uniqKey="Farrer M">MJ Farrer</name></author><author><name sortKey="Tan, Ek" uniqKey="Tan E">EK Tan</name></author><author><name sortKey="Wu, Rm" uniqKey="Wu R">RM Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Daniels, V" uniqKey="Daniels V">V Daniels</name></author><author><name sortKey="Baekelandt, V" uniqKey="Baekelandt V">V Baekelandt</name></author><author><name sortKey="Taymans, Jm" uniqKey="Taymans J">JM Taymans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yue, Z" uniqKey="Yue Z">Z Yue</name></author><author><name sortKey="Lachenmayer, Ml" uniqKey="Lachenmayer M">ML Lachenmayer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nandhagopal, R" uniqKey="Nandhagopal R">R Nandhagopal</name></author><author><name sortKey="Mak, E" uniqKey="Mak E">E Mak</name></author><author><name sortKey="Schulzer, M" uniqKey="Schulzer M">M Schulzer</name></author><author><name sortKey="Mckenzie, J" uniqKey="Mckenzie J">J McKenzie</name></author><author><name sortKey="Mccormick, S" uniqKey="Mccormick S">S McCormick</name></author><author><name sortKey="Sossi, V" uniqKey="Sossi V">V Sossi</name></author><author><name sortKey="Ruth, Tj" uniqKey="Ruth T">TJ Ruth</name></author><author><name sortKey="Strongosky, A" uniqKey="Strongosky A">A Strongosky</name></author><author><name sortKey="Farrer, Mj" uniqKey="Farrer M">MJ Farrer</name></author><author><name sortKey="Wszolek, Zk" uniqKey="Wszolek Z">ZK Wszolek</name></author><author><name sortKey="Stoessl, Aj" uniqKey="Stoessl A">AJ Stoessl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sossi, V" uniqKey="Sossi V">V Sossi</name></author><author><name sortKey="De La Fuente Fernandez, R" uniqKey="De La Fuente Fernandez R">R de la Fuente-Fernandez</name></author><author><name sortKey="Nandhagopal, R" uniqKey="Nandhagopal R">R Nandhagopal</name></author><author><name sortKey="Schulzer, M" uniqKey="Schulzer M">M Schulzer</name></author><author><name sortKey="Mckenzie, J" uniqKey="Mckenzie J">J McKenzie</name></author><author><name sortKey="Ruth, Tj" uniqKey="Ruth T">TJ Ruth</name></author><author><name sortKey="Aasly, Jo" uniqKey="Aasly J">JO Aasly</name></author><author><name sortKey="Farrer, Mj" uniqKey="Farrer M">MJ Farrer</name></author><author><name sortKey="Wszolek, Zk" uniqKey="Wszolek Z">ZK Wszolek</name></author><author><name sortKey="Stoessl, Ja" uniqKey="Stoessl J">JA Stoessl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bostantjopoulou, S" uniqKey="Bostantjopoulou S">S Bostantjopoulou</name></author><author><name sortKey="Katsarou, Z" uniqKey="Katsarou Z">Z Katsarou</name></author><author><name sortKey="Gerasimou, G" uniqKey="Gerasimou G">G Gerasimou</name></author><author><name sortKey="Costa, Dc" uniqKey="Costa D">DC Costa</name></author><author><name sortKey="Gotzamani Psarrakou, A" uniqKey="Gotzamani Psarrakou A">A Gotzamani-Psarrakou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perani, D" uniqKey="Perani D">D Perani</name></author><author><name sortKey="Garibotto, V" uniqKey="Garibotto V">V Garibotto</name></author><author><name sortKey="Hadjigeorgiou, Gm" uniqKey="Hadjigeorgiou G">GM Hadjigeorgiou</name></author><author><name sortKey="Papadimitriou, D" uniqKey="Papadimitriou D">D Papadimitriou</name></author><author><name sortKey="Fazio, F" uniqKey="Fazio F">F Fazio</name></author><author><name sortKey="Papadimitriou, A" uniqKey="Papadimitriou A">A Papadimitriou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Samii, A" uniqKey="Samii A">A Samii</name></author><author><name sortKey="Markopoulou, K" uniqKey="Markopoulou K">K Markopoulou</name></author><author><name sortKey="Wszolek, Zk" uniqKey="Wszolek Z">ZK Wszolek</name></author><author><name sortKey="Sossi, V" uniqKey="Sossi V">V Sossi</name></author><author><name sortKey="Dobko, T" uniqKey="Dobko T">T Dobko</name></author><author><name sortKey="Mak, E" uniqKey="Mak E">E Mak</name></author><author><name sortKey="Calne, Db" uniqKey="Calne D">DB Calne</name></author><author><name sortKey="Stoessl, Aj" uniqKey="Stoessl A">AJ Stoessl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Biskup, S" uniqKey="Biskup S">S Biskup</name></author><author><name sortKey="Moore, Dj" uniqKey="Moore D">DJ Moore</name></author><author><name sortKey="Rea, A" uniqKey="Rea A">A Rea</name></author><author><name sortKey="Lorenz Deperieux, B" uniqKey="Lorenz Deperieux B">B Lorenz-Deperieux</name></author><author><name sortKey="Coombes, Ce" uniqKey="Coombes C">CE Coombes</name></author><author><name sortKey="Dawson, Vl" uniqKey="Dawson V">VL Dawson</name></author><author><name sortKey="Dawson, Tm" uniqKey="Dawson T">TM Dawson</name></author><author><name sortKey="West, Ab" uniqKey="West A">AB West</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Biskup, S" uniqKey="Biskup S">S Biskup</name></author><author><name sortKey="Moore, Dj" uniqKey="Moore D">DJ Moore</name></author><author><name sortKey="Celsi, F" uniqKey="Celsi F">F Celsi</name></author><author><name sortKey="Higashi, S" uniqKey="Higashi S">S Higashi</name></author><author><name sortKey="West, Ab" uniqKey="West A">AB West</name></author><author><name sortKey="Andrabi, Sa" uniqKey="Andrabi S">SA Andrabi</name></author><author><name sortKey="Kurkinen, K" uniqKey="Kurkinen K">K Kurkinen</name></author><author><name sortKey="Yu, Sw" uniqKey="Yu S">SW Yu</name></author><author><name sortKey="Savitt, Jm" uniqKey="Savitt J">JM Savitt</name></author><author><name sortKey="Waldvogel, Hj" uniqKey="Waldvogel H">HJ Waldvogel</name></author><author><name sortKey="Faull, Rl" uniqKey="Faull R">RL Faull</name></author><author><name sortKey="Emson, Pc" uniqKey="Emson P">PC Emson</name></author><author><name sortKey="Torp, R" uniqKey="Torp R">R Torp</name></author><author><name sortKey="Ottersen, Op" uniqKey="Ottersen O">OP Ottersen</name></author><author><name sortKey="Dawson, Tm" uniqKey="Dawson T">TM Dawson</name></author><author><name sortKey="Dawson, Vl" uniqKey="Dawson V">VL Dawson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Galter, D" uniqKey="Galter D">D Galter</name></author><author><name sortKey="Westerlund, M" uniqKey="Westerlund M">M Westerlund</name></author><author><name sortKey="Carmine, A" uniqKey="Carmine A">A Carmine</name></author><author><name sortKey="Lindqvist, E" uniqKey="Lindqvist E">E Lindqvist</name></author><author><name sortKey="Sydow, O" uniqKey="Sydow O">O Sydow</name></author><author><name sortKey="Olson, L" uniqKey="Olson L">L Olson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Melrose, H" uniqKey="Melrose H">H Melrose</name></author><author><name sortKey="Lincoln, S" uniqKey="Lincoln S">S Lincoln</name></author><author><name sortKey="Tyndall, G" uniqKey="Tyndall G">G Tyndall</name></author><author><name sortKey="Dickson, D" uniqKey="Dickson D">D Dickson</name></author><author><name sortKey="Farrer, M" uniqKey="Farrer M">M Farrer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Simon Sanchez, J" uniqKey="Simon Sanchez J">J Simon-Sanchez</name></author><author><name sortKey="Herranz Perez, V" uniqKey="Herranz Perez V">V Herranz-Perez</name></author><author><name sortKey="Olucha Bordonau, F" uniqKey="Olucha Bordonau F">F Olucha-Bordonau</name></author><author><name sortKey="Perez Tur, J" uniqKey="Perez Tur J">J Perez-Tur</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taymans, Jm" uniqKey="Taymans J">JM Taymans</name></author><author><name sortKey="Van Den Haute, C" uniqKey="Van Den Haute C">C Van den Haute</name></author><author><name sortKey="Baekelandt, V" uniqKey="Baekelandt V">V Baekelandt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Melrose, Hl" uniqKey="Melrose H">HL Melrose</name></author><author><name sortKey="Kent, Cb" uniqKey="Kent C">CB Kent</name></author><author><name sortKey="Taylor, Jp" uniqKey="Taylor J">JP Taylor</name></author><author><name sortKey="Dachsel, Jc" uniqKey="Dachsel J">JC Dachsel</name></author><author><name sortKey="Hinkle, Km" uniqKey="Hinkle K">KM Hinkle</name></author><author><name sortKey="Lincoln, Sj" uniqKey="Lincoln S">SJ Lincoln</name></author><author><name sortKey="Mok, Ss" uniqKey="Mok S">SS Mok</name></author><author><name sortKey="Culvenor, Jg" uniqKey="Culvenor J">JG Culvenor</name></author><author><name sortKey="Masters, Cl" uniqKey="Masters C">CL Masters</name></author><author><name sortKey="Tyndall, Gm" uniqKey="Tyndall G">GM Tyndall</name></author><author><name sortKey="Bass, Di" uniqKey="Bass D">DI Bass</name></author><author><name sortKey="Ahmed, Z" uniqKey="Ahmed Z">Z Ahmed</name></author><author><name sortKey="Andorfer, Ca" uniqKey="Andorfer C">CA Andorfer</name></author><author><name sortKey="Ross, Oa" uniqKey="Ross O">OA Ross</name></author><author><name sortKey="Wszolek, Zk" uniqKey="Wszolek Z">ZK Wszolek</name></author><author><name sortKey="Delldonne, A" uniqKey="Delldonne A">A Delldonne</name></author><author><name sortKey="Dickson, Dw" uniqKey="Dickson D">DW Dickson</name></author><author><name sortKey="Farrer, Mj" uniqKey="Farrer M">MJ Farrer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shi, Wx" uniqKey="Shi W">WX Shi</name></author><author><name sortKey="Pun, Cl" uniqKey="Pun C">CL Pun</name></author><author><name sortKey="Smith, Pl" uniqKey="Smith P">PL Smith</name></author><author><name sortKey="Bunney, Bs" uniqKey="Bunney B">BS Bunney</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dachsel, Jc" uniqKey="Dachsel J">JC Dachsel</name></author><author><name sortKey="Behrouz, B" uniqKey="Behrouz B">B Behrouz</name></author><author><name sortKey="Yue, M" uniqKey="Yue M">M Yue</name></author><author><name sortKey="Beevers, Je" uniqKey="Beevers J">JE Beevers</name></author><author><name sortKey="Melrose, Hl" uniqKey="Melrose H">HL Melrose</name></author><author><name sortKey="Farrer, Mj" uniqKey="Farrer M">MJ Farrer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Winner, B" uniqKey="Winner B">B Winner</name></author><author><name sortKey="Melrose, Hl" uniqKey="Melrose H">HL Melrose</name></author><author><name sortKey="Zhao, C" uniqKey="Zhao C">C Zhao</name></author><author><name sortKey="Hinkle, Km" uniqKey="Hinkle K">KM Hinkle</name></author><author><name sortKey="Yue, M" uniqKey="Yue M">M Yue</name></author><author><name sortKey="Kent, C" uniqKey="Kent C">C Kent</name></author><author><name sortKey="Braithwaite, At" uniqKey="Braithwaite A">AT Braithwaite</name></author><author><name sortKey="Ogholikhan, S" uniqKey="Ogholikhan S">S Ogholikhan</name></author><author><name sortKey="Aigner, R" uniqKey="Aigner R">R Aigner</name></author><author><name sortKey="Winkler, J" uniqKey="Winkler J">J Winkler</name></author><author><name sortKey="Farrer, Mj" uniqKey="Farrer M">MJ Farrer</name></author><author><name sortKey="Gage, Fh" uniqKey="Gage F">FH Gage</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parisiadou, L" uniqKey="Parisiadou L">L Parisiadou</name></author><author><name sortKey="Xie, C" uniqKey="Xie C">C Xie</name></author><author><name sortKey="Cho, Hj" uniqKey="Cho H">HJ Cho</name></author><author><name sortKey="Lin, X" uniqKey="Lin X">X Lin</name></author><author><name sortKey="Gu, Xl" uniqKey="Gu X">XL Gu</name></author><author><name sortKey="Long, Cx" uniqKey="Long C">CX Long</name></author><author><name sortKey="Lobbestael, E" uniqKey="Lobbestael E">E Lobbestael</name></author><author><name sortKey="Baekelandt, V" uniqKey="Baekelandt V">V Baekelandt</name></author><author><name sortKey="Taymans, Jm" uniqKey="Taymans J">JM Taymans</name></author><author><name sortKey="Sun, L" uniqKey="Sun L">L Sun</name></author><author><name sortKey="Cai, H" uniqKey="Cai H">H Cai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parisiadou, L" uniqKey="Parisiadou L">L Parisiadou</name></author><author><name sortKey="Cai, H" uniqKey="Cai H">H Cai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, D" uniqKey="Chan D">D Chan</name></author><author><name sortKey="Citro, A" uniqKey="Citro A">A Citro</name></author><author><name sortKey="Cordy, Jm" uniqKey="Cordy J">JM Cordy</name></author><author><name sortKey="Shen, Gc" uniqKey="Shen G">GC Shen</name></author><author><name sortKey="Wolozin, B" uniqKey="Wolozin B">B Wolozin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kicka, S" uniqKey="Kicka S">S Kicka</name></author><author><name sortKey="Shen, Z" uniqKey="Shen Z">Z Shen</name></author><author><name sortKey="Annesley, Sj" uniqKey="Annesley S">SJ Annesley</name></author><author><name sortKey="Fisher, Pr" uniqKey="Fisher P">PR Fisher</name></author><author><name sortKey="Lee, S" uniqKey="Lee S">S Lee</name></author><author><name sortKey="Briggs, S" uniqKey="Briggs S">S Briggs</name></author><author><name sortKey="Firtel, Ra" uniqKey="Firtel R">RA Firtel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meixner, A" uniqKey="Meixner A">A Meixner</name></author><author><name sortKey="Boldt, K" uniqKey="Boldt K">K Boldt</name></author><author><name sortKey="Van Troys, M" uniqKey="Van Troys M">M Van Troys</name></author><author><name sortKey="Askenazi, M" uniqKey="Askenazi M">M Askenazi</name></author><author><name sortKey="Gloeckner, Cj" uniqKey="Gloeckner C">CJ Gloeckner</name></author><author><name sortKey="Bauer, M" uniqKey="Bauer M">M Bauer</name></author><author><name sortKey="Marto, Ja" uniqKey="Marto J">JA Marto</name></author><author><name sortKey="Ampe, C" uniqKey="Ampe C">C Ampe</name></author><author><name sortKey="Kinkl, N" uniqKey="Kinkl N">N Kinkl</name></author><author><name sortKey="Ueffing, M" uniqKey="Ueffing M">M Ueffing</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jedynak, Jp" uniqKey="Jedynak J">JP Jedynak</name></author><author><name sortKey="Uslaner, Jm" uniqKey="Uslaner J">JM Uslaner</name></author><author><name sortKey="Esteban, Ja" uniqKey="Esteban J">JA Esteban</name></author><author><name sortKey="Robinson, Te" uniqKey="Robinson T">TE Robinson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Couillard Despres, S" uniqKey="Couillard Despres S">S Couillard-Despres</name></author><author><name sortKey="Winner, B" uniqKey="Winner B">B Winner</name></author><author><name sortKey="Schaubeck, S" uniqKey="Schaubeck S">S Schaubeck</name></author><author><name sortKey="Aigner, R" uniqKey="Aigner R">R Aigner</name></author><author><name sortKey="Vroemen, M" uniqKey="Vroemen M">M Vroemen</name></author><author><name sortKey="Weidner, N" uniqKey="Weidner N">N Weidner</name></author><author><name sortKey="Bogdahn, U" uniqKey="Bogdahn U">U Bogdahn</name></author><author><name sortKey="Winkler, J" uniqKey="Winkler J">J Winkler</name></author><author><name sortKey="Kuhn, Hg" uniqKey="Kuhn H">HG Kuhn</name></author><author><name sortKey="Aigner, L" uniqKey="Aigner L">L Aigner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tong, Y" uniqKey="Tong Y">Y Tong</name></author><author><name sortKey="Yamaguchi, H" uniqKey="Yamaguchi H">H Yamaguchi</name></author><author><name sortKey="Giaime, E" uniqKey="Giaime E">E Giaime</name></author><author><name sortKey="Boyle, S" uniqKey="Boyle S">S Boyle</name></author><author><name sortKey="Kopan, R" uniqKey="Kopan R">R Kopan</name></author><author><name sortKey="Kelleher, Rj" uniqKey="Kelleher R">RJ Kelleher</name></author><author><name sortKey="Shen, J" uniqKey="Shen J">J Shen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hall, C" uniqKey="Hall C">C Hall</name></author><author><name sortKey="Ballachey, El" uniqKey="Ballachey E">EL Ballachey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Corman, Cd" uniqKey="Corman C">CD Corman</name></author><author><name sortKey="Shafer, Jn" uniqKey="Shafer J">JN Shafer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Royce, Jr" uniqKey="Royce J">JR Royce</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lauterbach, Ec" uniqKey="Lauterbach E">EC Lauterbach</name></author><author><name sortKey="Duvoisin, Rc" uniqKey="Duvoisin R">RC Duvoisin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nilsson, Fm" uniqKey="Nilsson F">FM Nilsson</name></author><author><name sortKey="Kessing, Lv" uniqKey="Kessing L">LV Kessing</name></author><author><name sortKey="Bolwig, Tg" uniqKey="Bolwig T">TG Bolwig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhu, Xr" uniqKey="Zhu X">XR Zhu</name></author><author><name sortKey="Maskri, L" uniqKey="Maskri L">L Maskri</name></author><author><name sortKey="Herold, C" uniqKey="Herold C">C Herold</name></author><author><name sortKey="Bader, V" uniqKey="Bader V">V Bader</name></author><author><name sortKey="Stichel, Cc" uniqKey="Stichel C">CC Stichel</name></author><author><name sortKey="Gunturkun, O" uniqKey="Gunturkun O">O Gunturkun</name></author><author><name sortKey="Lubbert, H" uniqKey="Lubbert H">H Lubbert</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Brown, Re" uniqKey="Brown R">RE Brown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Herzig, Mc" uniqKey="Herzig M">MC Herzig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tong, Y" uniqKey="Tong Y">Y Tong</name></author><author><name sortKey="Giaime, E" uniqKey="Giaime E">E Giaime</name></author><author><name sortKey="Yamaguchi, H" uniqKey="Yamaguchi H">H Yamaguchi</name></author><author><name sortKey="Ichimura, T" uniqKey="Ichimura T">T Ichimura</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name></author><author><name sortKey="Si, H" uniqKey="Si H">H Si</name></author><author><name sortKey="Cai, H" uniqKey="Cai H">H Cai</name></author><author><name sortKey="Bonventre, Jv" uniqKey="Bonventre J">JV Bonventre</name></author><author><name sortKey="Shen, J" uniqKey="Shen J">J Shen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wahlsten, D" uniqKey="Wahlsten D">D Wahlsten</name></author><author><name sortKey="Metten, P" uniqKey="Metten P">P Metten</name></author><author><name sortKey="Phillips, Tj" uniqKey="Phillips T">TJ Phillips</name></author><author><name sortKey="Boehm, Sl" uniqKey="Boehm S">SL Boehm</name></author><author><name sortKey="Burkhart Kasch, S" uniqKey="Burkhart Kasch S">S Burkhart-Kasch</name></author><author><name sortKey="Dorow, J" uniqKey="Dorow J">J Dorow</name></author><author><name sortKey="Doerksen, S" uniqKey="Doerksen S">S Doerksen</name></author><author><name sortKey="Downing, C" uniqKey="Downing C">C Downing</name></author><author><name sortKey="Fogarty, J" uniqKey="Fogarty J">J Fogarty</name></author><author><name sortKey="Rodd Henricks, K" uniqKey="Rodd Henricks K">K Rodd-Henricks</name></author><author><name sortKey="Hen, R" uniqKey="Hen R">R Hen</name></author><author><name sortKey="Mckinnon, Cs" uniqKey="Mckinnon C">CS McKinnon</name></author><author><name sortKey="Merrill, Cm" uniqKey="Merrill C">CM Merrill</name></author><author><name sortKey="Nolte, C" uniqKey="Nolte C">C Nolte</name></author><author><name sortKey="Schalomon, M" uniqKey="Schalomon M">M Schalomon</name></author><author><name sortKey="Schlumbohm, Jp" uniqKey="Schlumbohm J">JP Schlumbohm</name></author><author><name sortKey="Sibert, Jr" uniqKey="Sibert J">JR Sibert</name></author><author><name sortKey="Wenger, Cd" uniqKey="Wenger C">CD Wenger</name></author><author><name sortKey="Dudek, Bc" uniqKey="Dudek B">BC Dudek</name></author><author><name sortKey="Crabbe, Jc" uniqKey="Crabbe J">JC Crabbe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lipp, Hp" uniqKey="Lipp H">HP Lipp</name></author><author><name sortKey="Wolfer, Dp" uniqKey="Wolfer D">DP Wolfer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Melrose, Hl" uniqKey="Melrose H">HL Melrose</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hyde, La" uniqKey="Hyde L">LA Hyde</name></author><author><name sortKey="Crnic, Ls" uniqKey="Crnic L">LS Crnic</name></author><author><name sortKey="Pollock, A" uniqKey="Pollock A">A Pollock</name></author><author><name sortKey="Bickford, Pc" uniqKey="Bickford P">PC Bickford</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gerlai, R" uniqKey="Gerlai R">R Gerlai</name></author><author><name sortKey="Pisacane, P" uniqKey="Pisacane P">P Pisacane</name></author><author><name sortKey="Erickson, S" uniqKey="Erickson S">S Erickson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vitali, R" uniqKey="Vitali R">R Vitali</name></author><author><name sortKey="Clarke, S" uniqKey="Clarke S">S Clarke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clabough, Eb" uniqKey="Clabough E">EB Clabough</name></author><author><name sortKey="Zeitlin, So" uniqKey="Zeitlin S">SO Zeitlin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sahay, A" uniqKey="Sahay A">A Sahay</name></author><author><name sortKey="Drew, Mr" uniqKey="Drew M">MR Drew</name></author><author><name sortKey="Hen, R" uniqKey="Hen R">R Hen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sahay, A" uniqKey="Sahay A">A Sahay</name></author><author><name sortKey="Hen, R" uniqKey="Hen R">R Hen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kontgen, F" uniqKey="Kontgen F">F Kontgen</name></author><author><name sortKey="Suss, G" uniqKey="Suss G">G Suss</name></author><author><name sortKey="Stewart, C" uniqKey="Stewart C">C Stewart</name></author><author><name sortKey="Steinmetz, M" uniqKey="Steinmetz M">M Steinmetz</name></author><author><name sortKey="Bluethmann, H" uniqKey="Bluethmann H">H Bluethmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paxinos, G" uniqKey="Paxinos G">G Paxinos</name></author><author><name sortKey="Franklin, K" uniqKey="Franklin K">K Franklin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wolfer, Dp" uniqKey="Wolfer D">DP Wolfer</name></author><author><name sortKey="Madani, R" uniqKey="Madani R">R Madani</name></author><author><name sortKey="Valenti, P" uniqKey="Valenti P">P Valenti</name></author><author><name sortKey="Lipp, Hp" uniqKey="Lipp H">HP Lipp</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kale, A" uniqKey="Kale A">A Kale</name></author><author><name sortKey="Amende, I" uniqKey="Amende I">I Amende</name></author><author><name sortKey="Meyer, Gp" uniqKey="Meyer G">GP Meyer</name></author><author><name sortKey="Crabbe, Jc" uniqKey="Crabbe J">JC Crabbe</name></author><author><name sortKey="Hampton, Tg" uniqKey="Hampton T">TG Hampton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Amende, I" uniqKey="Amende I">I Amende</name></author><author><name sortKey="Kale, A" uniqKey="Kale A">A Kale</name></author><author><name sortKey="Mccue, S" uniqKey="Mccue S">S McCue</name></author><author><name sortKey="Glazier, S" uniqKey="Glazier S">S Glazier</name></author><author><name sortKey="Morgan, Jp" uniqKey="Morgan J">JP Morgan</name></author><author><name sortKey="Hampton, Tg" uniqKey="Hampton T">TG Hampton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goldberg, Nr" uniqKey="Goldberg N">NR Goldberg</name></author><author><name sortKey="Hampton, T" uniqKey="Hampton T">T Hampton</name></author><author><name sortKey="Mccue, S" uniqKey="Mccue S">S McCue</name></author><author><name sortKey="Kale, A" uniqKey="Kale A">A Kale</name></author><author><name sortKey="Meshul, Ck" uniqKey="Meshul C">CK Meshul</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hamers, Fp" uniqKey="Hamers F">FP Hamers</name></author><author><name sortKey="Lankhorst, Aj" uniqKey="Lankhorst A">AJ Lankhorst</name></author><author><name sortKey="Van Laar, Tj" uniqKey="Van Laar T">TJ van Laar</name></author><author><name sortKey="Veldhuis, Wb" uniqKey="Veldhuis W">WB Veldhuis</name></author><author><name sortKey="Gispen, Wh" uniqKey="Gispen W">WH Gispen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morel, P" uniqKey="Morel P">P Morel</name></author><author><name sortKey="Fauconneau, B" uniqKey="Fauconneau B">B Fauconneau</name></author><author><name sortKey="Page, G" uniqKey="Page G">G Page</name></author><author><name sortKey="Mirbeau, T" uniqKey="Mirbeau T">T Mirbeau</name></author><author><name sortKey="Huguet, F" uniqKey="Huguet F">F Huguet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bradford, Mm" uniqKey="Bradford M">MM Bradford</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moron, Ja" uniqKey="Moron J">JA Moron</name></author><author><name sortKey="Perez, V" uniqKey="Perez V">V Perez</name></author><author><name sortKey="Fernandez Alvarez, E" uniqKey="Fernandez Alvarez E">E Fernandez-Alvarez</name></author><author><name sortKey="Marco, Jl" uniqKey="Marco J">JL Marco</name></author><author><name sortKey="Unzeta, M" uniqKey="Unzeta M">M Unzeta</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Canada</li><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Hinkle, Kelly M" sort="Hinkle, Kelly M" uniqKey="Hinkle K" first="Kelly M" last="Hinkle">Kelly M. Hinkle</name></noRegion><name sortKey="Beevers, Joel E" sort="Beevers, Joel E" uniqKey="Beevers J" first="Joel E" last="Beevers">Joel E. Beevers</name><name sortKey="Behrouz, Bahareh" sort="Behrouz, Bahareh" uniqKey="Behrouz B" first="Bahareh" last="Behrouz">Bahareh Behrouz</name><name sortKey="Bowles, Erin E" sort="Bowles, Erin E" uniqKey="Bowles E" first="Erin E" last="Bowles">Erin E. Bowles</name><name sortKey="D Chsel, Justus C" sort="D Chsel, Justus C" uniqKey="D Chsel J" first="Justus C" last="D Chsel">Justus C. D Chsel</name><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W" last="Dickson">Dennis W. Dickson</name><name sortKey="Dugger, Brittany" sort="Dugger, Brittany" uniqKey="Dugger B" first="Brittany" last="Dugger">Brittany Dugger</name><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J" last="Farrer">Matthew J. Farrer</name><name sortKey="Janus, Christopher J" sort="Janus, Christopher J" uniqKey="Janus C" first="Christopher J" last="Janus">Christopher J. Janus</name><name sortKey="Kent, Caroline B" sort="Kent, Caroline B" uniqKey="Kent C" first="Caroline B" last="Kent">Caroline B. Kent</name><name sortKey="Lin, Wen Lang" sort="Lin, Wen Lang" uniqKey="Lin W" first="Wen-Lang" last="Lin">Wen-Lang Lin</name><name sortKey="Lincoln, Sarah J" sort="Lincoln, Sarah J" uniqKey="Lincoln S" first="Sarah J" last="Lincoln">Sarah J. Lincoln</name><name sortKey="Melrose, Heather L" sort="Melrose, Heather L" uniqKey="Melrose H" first="Heather L" last="Melrose">Heather L. Melrose</name><name sortKey="Nishioka, Kenya" sort="Nishioka, Kenya" uniqKey="Nishioka K" first="Kenya" last="Nishioka">Kenya Nishioka</name><name sortKey="Yue, Mei" sort="Yue, Mei" uniqKey="Yue M" first="Mei" last="Yue">Mei Yue</name></country><country name="Allemagne"><noRegion><name sortKey="Winner, Beate" sort="Winner, Beate" uniqKey="Winner B" first="Beate" last="Winner">Beate Winner</name></noRegion><name sortKey="Prots, Iryna" sort="Prots, Iryna" uniqKey="Prots I" first="Iryna" last="Prots">Iryna Prots</name></country><country name="Canada"><noRegion><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J" last="Farrer">Matthew J. Farrer</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001302 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001302 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3441373
|texte= LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:22647713" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |